AG Siegmund "Intestinal Inflammation and Tumor Immunology"

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Research interest

The main subjects of our work are the mechanisms of intestinal inflammation with special emphasis on T cells and myeloid cells but also the epithelial barrier. Since the founding of the group, we have a special interest in the role of the adipose tissue in the pathogenesis of chronic intestinal inflammation and its impact on the mucosal immune system. Additionally, we are interested in the immune evasion of tumors regarding the regulatory function of myeloid cells as well as CD8+ T cell activation.

Both subjects are investigated regarding the metabolic changes in the local microenvironment and epigenetic regulation of the respective cells via histone deacetylases.


Univ.-Prof. Dr. med. Britta Siegmund

Director Medical Center for Gastroenterology, Infectiology and Rheumatology

CBF: Campus Benjamin Franklin


01.10.2020  We welcome a new member of our team
Max Brunkhorst joins the lab as clinician scientist.

28.08.2020 Scholarships aquired
Cansu Yerinde and Lorenz Gerbeth both aquired the competitive "Promotionsabschlussstipendium I" (graduation scholarship) of the Charité Nachwuchskommission, which covers one year of funding.

03.08.2020 Yasmina Rodriguez Sillke leaves the group
After almost four years in our labs and after finishing the experimental part of her thesis, Yasmina joins the Charité/BIH - Cytometry Core. We wish her all the best.