Department of Gastroenterology, Infectious Diseases and Rheumatology (including Clinical Nutrition) 

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AG Siegmund "Intestinal Inflammation and Tumor Immunology"

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Research interest

The main subjects of our work are the mechanisms of intestinal inflammation with special emphasis on T cells and myeloid cells but also the epithelial barrier. Since the founding of the group, we have a special interest in the role of the adipose tissue in the pathogenesis of chronic intestinal inflammation and its impact on the mucosal immune system. Additionally, we are interested in the immune evasion of tumors regarding the regulatory function of myeloid cells as well as CD8+ T cell activation.

Both subjects are investigated regarding the metabolic changes in the local microenvironment and epigenetic regulation of the respective cells via histone deacetylases.


Univ.-Prof. Dr. med. Britta Siegmund

Director Medical Center for Gastroenterology, Infectiology and Rheumatology

CBF: Campus Benjamin Franklin


13.06.2022 Publication accepted
(Cooperation with Ahmed Hegazy and Thomas Schneider from our Department)
"Anti-SARS-CoV2 antibody-mediated cytokine release syndrome in a patient with acute promyelocytic leukemia"
BMC Infectious Diseases

27.05.2022 Collaborative Research Center/ Transregio (TRR) 241
„Immun-Epithelial Communication in Inflammatory Bowel Disease“ extended.
- Project: "Mesenteric Fat - an immunological barrier in Crohn's Disease?"

12.04.2022 Editorial accepted
"Epithelial RAC1 niches in IBD: from barrier integrity to cytoskeletal plasticity."