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The main subjects of our work are the mechanisms of intestinal inflammation with special emphasis on T cells and myeloid cells but also the epithelial barrier. Since the founding of the group, we have a special interest in the role of the adipose tissue in the pathogenesis of chronic intestinal inflammation and its impact on the mucosal immune system. Additionally, we are interested in the immune evasion of tumors regarding the regulatory function of myeloid cells as well as CD8+ T cell activation.
Both subjects are investigated regarding the metabolic changes in the local microenvironment and epigenetic regulation of the respective cells via histone deacetylases.
26.10.2023 Scipio Single-cell Grant acquired
Adrian Huck and Rainer Glauben acquired the "2023 Single-cell Grant" from Scipio bioscience, worth $30,000 of material and services.
02.10.2023 We welcome a new member of our team
Hans Gluschke joins the lab as clinician scientist.
24.09.2023 Publication accepted
(Cooperation with the AG Keller from our hematology department)
"Activation of gp130 signaling in T-cells drives TH17-mediated multi-organ autoimmunity"