AG Siegmund "Intestinal Inflammation and Tumor Immunology"

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Research interest

The main subjects of our work are the mechanisms of intestinal inflammation with special emphasis on T cells and myeloid cells but also the epithelial barrier. Since the founding of the group, we have a special interest in the role of the adipose tissue in the pathogenesis of chronic intestinal inflammation and its impact on the mucosal immune system. Additionally, we are interested in the immune evasion of tumors regarding the regulatory function of myeloid cells as well as CD8+ T cell activation.

Both subjects are investigated regarding the metabolic changes in the local microenvironment and epigenetic regulation of the respective cells via histone deacetylases.

Head

Univ.-Prof. Dr. med. Britta Siegmund

Director Medical Center for Gastroenterology, Infectiology and Rheumatology

CBF: Campus Benjamin Franklin

News

19.02.2021 A Review has been published
"COVID-19—from mucosal immunology to IBD patients"
Mucosal Immunology
https://doi.org/10.1038/s41385-021-00384-9

01.01.2021 DKTK Research Grant starting
Lea-Maxie Haag aquired the "Initial Funding within the Young Investigator Grant of the German Cancer Consortium (DKTK)"

26.11.2020 Collaborative Research Center (SFB) 1449 "Dynamic Hydrogels at Biointerfaces" accepted
- Projekt "Hydrogel properties on intestinal surfaces in health and disease" in collaboration with AG Weinhart (FU Berlin)
- Core unit: "In vitro and in vivo hydrogel model systems core unit" in collaboration with AG Weinhart and AG Mall (BIH)