Department of Gastroenterology, Infectious Diseases and Rheumatology (including Clinical Nutrition) 

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Publications of the AG Siegmund "Intestinal Inflammation and Tumor Immunology"

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Publications (selected since 2019)

Letizia M, Wang YH, Kaufmann U, Gerbeth L, Sand A, Brunkhorst M, Weidner P, Ziegler JF, Böttcher C, Schlickeiser S, Fernández C, Yamashita M, Stauderman K, Sun K, Kunkel D, Prakriya M; IBDome Researchers, Sanders AD, Siegmund B, Feske S, Weidinger C. Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.EMBO Mol Med. 2022 Aug 2:e15687.

Atreya R., Siegmund B. Location is important: differentiation between ileal and colonic Crohn's disease. Nat Rev Gastroenterol Hepatol. 2021 doi: 10.1038/s41575-021-00424-6. Online ahead of print.

Jessen B, Rodriguez-Sillke Y, Sonnenberg E, Schumann M, Kruglov A, Freise I, Schmidt F, Maul J, Kühl AA, Glauben R, Lissner D, Siegmund B. Level of Tumor Necrosis Factor Production by Stimulated Blood Mononuclear Cells Can Be Used to Predict Response of Patients With Inflammatory Bowel Diseases to Infliximab. Clin Gastroenterol Hepatol. 2020 S1542-3565(20)30443-2.

Ziegler, J. F., C. Bottcher, M. Letizia, C. Yerinde, H. Wu, I. Freise, Y. Rodriguez-Sillke, A. K. Stoyanova, M. E. Kreis, P. Asbach, D. Kunkel, J. Priller, I. Anagnostopoulos, A. A. Kuhl, K. Miehle, M. Stumvoll, F. Tran, B. Fredrich, M. Forster, A. Franke, C. Bojarski, R. Glauben, B. S. Loscher, B. Siegmund, and C. Weidinger. Leptin induces TNFalpha-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease. Nat Commun 2019. 10: 5629.

Wu, H., Y. Han, Y. Rodriguez Sillke, H. Deng, S. Siddiqui, C. Treese, F. Schmidt, M. Friedrich, J. Keye, J. Wan, Y. Qin, A. A. Kuhl, Z. Qin, B. Siegmund, and R. Glauben. Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages. EMBO Mol Med 2019. 11: e10698.

Visekruna, A., S. Hartmann, Y. R. Sillke, R. Glauben, F. Fischer, H. Raifer, H. Mollenkopf, W. Bertrams, B. Schmeck, M. Klein, A. Pagenstecher, M. Lohoff, R. Jacob, O. Pabst, P. W. Bland, M. Luu, R. Romero, B. Siegmund, K. Rajalingam, and U. Steinhoff. Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest 2019. 129: 1972-1983.

Schmidt, F., K. Dahlke, A. Batra, J. Keye, H. Wu, M. Friedrich, R. Glauben, C. Ring, G. Loh, M. Schaubeck, H. Hackl, Z. Trajanoski, M. Schumann, A. A. Kuhl, M. Blaut, and B. Siegmund. Microbial Colonization in Adulthood Shapes the Intestinal Macrophage Compartment. J Crohns Colitis 2019. 13: 1173-1185.

Kredel, L. I., L. J. Jodicke, A. Scheffold, J. Grone, R. Glauben, U. Erben, A. A. Kuhl, and B. Siegmund. T-cell Composition in Ileal and Colonic Creeping Fat - Separating Ileal from Colonic Crohn's Disease. J Crohns Colitis 2019. 13: 79-91.

Friedrich, M., L. Gerbeth, M. Gerling, R. Rosenthal, K. Steiger, C. Weidinger, J. Keye, H. Wu, F. Schmidt, W. Weichert, B. Siegmund, and R. Glauben. HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFbeta1 signalling in inflammation. Mucosal immunology 2019. 12: 656-667.

Bottcher, C., S. Schlickeiser, M. A. M. Sneeboer, D. Kunkel, A. Knop, E. Paza, P. Fidzinski, L. Kraus, G. J. L. Snijders, R. S. Kahn, A. R. Schulz, H. E. Mei, N. B. B. Psy, E. M. Hol, B. Siegmund, R. Glauben, E. J. Spruth, L. D. de Witte, and J. Priller. Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry. Nat Neurosci 2019. 22: 78-90.


For a full list of the work group please follow this link to the respective Pub Med query.