News der AG Siegmund "Chronische Darmentzündung"
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13.06.2022 Publication accepted
(Cooperation with Ahmed Hegazy and Thomas Schneider from our Department)
"Anti-SARS-CoV2 antibody-mediated cytokine release syndrome in a patient with acute promyelocytic leukemia"
BMC Infectious Diseases
27.05.2022 Collaborative Research Center/ Transregio (TRR) 241
„Immun-Epithelial Communication in Inflammatory Bowel Disease“ extended.
- Project: "Mesenteric Fat - an immunological barrier in Crohn's Disease?"
12.04.2022 Editorial accepted
"Epithelial RAC1 niches in IBD: from barrier integrity to cytoskeletal plasticity."
04.04.2022 We welcome a new member of our team
Catharina Kramer joins the lab as clinician scientist.
04.04.2022 Editorial accepted
"Targeting SOCE in intestinal epithelial cells as a new treatment concept for IBD?"
01.04.2022 Marina Kolesnichenko leaves the group
Marina joins the colleagues from the Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie at the Campus Virchow Klinikum.
08.03.2022 Publication accepted
(Cooperation with AG Keller, Department of Hematology, Oncology and Cancer Immunology, Charité)
"Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer"
Journal of Clinical Investigation
28.02.2022 Cansu Yerinde and Lorenz Gerbeth leaving
After about five years in our labs, Cansu Yerinde and Lorenz Gerbeth leave the group. We wish them all the best.
07.02.2022 Publication accepted
(Cooperation with AG von Schwarzenberg, Department of Endocrinology & Metabolism, Charité)
"Effects of caloric restriction on the gut microbiome are linked with immune senescence"
21.01.2022 Short Talk Award acquired
Marilena Letizia was awarded the Short Talk Award of the "5th German Mass Cytometry User Forum"
19.01.22 Publication accepted
(Cooperation with AG Scheffold, Institute of Immunology, Christian-Albrechts-University of Kiel)
"A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4 + T cells and is defective in Crohn´s disease patients "
11.01.2022 Publication accepted
"Early onset of TNFα-driven arthritis, auto-inflammation and progressive loss of vision in a patient with ALPK1 mutation"
Journal of Clinical Immunology
05.01.2022 A Review has been published
"Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion"
09.12.2021 Publication accepted
(Cooperation with AG Rauch, Medizinische Klinik für Kardiologie, Charité)
"Pleiotropic effects of the protease-activated receptor 1 (PAR1)
inhibitor, vorapaxar, on atherosclerosis and vascular inflammation"
19.10.2021 Cansu Yerinde successfully defended her PhD thesis.
We congratulate Dr. rer. nat. Yerinde on her graduation.
03.08.2021 Publication accepted
"Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells"
12.07.2021 ECRT seed grant acquired
Our team, consisting of Max Brunkhorst, Lorenz Gerbeth, Marcus Lindner (from the AG Weinhart, FU Berlin) and Jörn Ziegler (alphabetical order), acquired the "Einstein Kickbox - Young Scientist grant within the Einstein Center for Regenerative Therapies (ECRT)"
23.06.2021 Publication accepted
(Cooperation with AG Qin, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China)
"Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes"
19.06.2021 Research award acquired
Carl Weidinger was awarded the DACED Zukunftspreis 2021
15.06.2021 "BIH Translation Hub Organoids and Cell Engineering" Grant accepted
"To investigate the influence of Store-Operated Calcium Entry on the homeostasis of intestinal epithelial cells"
15.06.2021 We welcome a new member of our team
Marina Kolesnichenko joins the lab as a new PI.
11.06.2021 Poster prize acquired
Marliena Letizia won the poster prize of the "Vision 2030: Changing Paradigms in IBD" conference.
03.05.2021 We welcome a new member of our team
Nadra Alzain joins the lab as research scientist / PhD student.
11.04.2021 Publication accepted
(Cooperation with AG Mechsner, Endometriosis Research Center, Charité)
"Functional changes of immune cells: signal of immune tolerance of the ectopic lesions in endometriosis?"
Reproductive BioMedicine Online
26.03.2021 A Review has been published
"Histone Deacetylases in the Inflamed Intestinal Epithelium-Promises of New Therapeutic Strategies"
Frontiers in Medicine
20.03.2021 A book chapter has been published
"Fatty AcidDriven Polarization of Suppressive Bone MarrowDerived Macrophages Including Metabolic and Functional Analysis"
Metastasis: Methods in Molecular Biology
12.03.2021 A Review has been published
"Location is important: differentiation between ileal and colonic Crohn’s disease"
Nature Reviews Gastroenterology & Hepatology
09.03.2021 Yasmina Rodriguez Sillke successfully defended her PhD thesis.
We congratulate Dr. rer. nat. Rodriguez Sillke on her graduation.
25.02.2021 A Review has been published
"Recognition of food antigens by the mucosal and systemic immune system: Consequences for intestinal development and homeostasis"
International Journal of Medical Microbiology
19.02.2021 A Review has been published
"COVID-19—from mucosal immunology to IBD patients"
01.01.2021 DKTK Research Grant starting
Lea-Maxie Haag acquired the "Initial Funding within the Young Investigator Grant of the German Cancer Consortium (DKTK)"
26.11.2020 Collaborative Research Center (SFB) 1449 "Dynamic Hydrogels at Biointerfaces" accepted
- Projekt "Hydrogel properties on intestinal surfaces in health and disease" in collaboration with AG Weinhart (FU Berlin)
- Core unit: "In vitro and in vivo hydrogel model systems core unit" in collaboration with AG Weinhart and AG Mall (BIH)
15.11.2020 We welcome a new member of our team
Adrian Huck joins the lab as research scientist / PhD student.
01.10.2020 We welcome a new member of our team
Max Brunkhorst joins the lab as clinician scientist.
28.08.2020 Scholarships acquired
Cansu Yerinde and Lorenz Gerbeth both acquired the competitive "Promotionsabschlussstipendium I" (graduation scholarship) of the Charité Nachwuchskommission, which covers one year of funding.
03.08.2020 Yasmina Rodriguez Sillke leaves the group
After almost four years in our labs and after finishing the experimental part of her thesis, Yasmina joins the Charité/BIH - Cytometry Core. We wish her all the best.
05.06.2020 Poster prize acquired
Marilena Letizia was awarded the poster prize of the TRR241 iRTG for "The pharmacologic inhibition of Store-operated Calcium Entry pathwy in inflammatory bowel disease"
18.05.2020 DFG Research Grant accepted
"Der Fettsäuremetabolismus immunsuppressiver myeloider Zellen in der Tumormikroumgebung als neues therapeutisches Ziel."
11.05.2020 Publication accepted
(Cooperation with the Stein Lab "Translational Oncology of Solid Tumors", MDC)
"Pro-inflammatory TNF-a and IFN-g Promote Tumor Growth and Metastasis via Induction of MACC1"
Frontiers in Immunology
01.04.2020 We welcome a new member of our team
Julia Hecker joins the lab as research scientist / PhD student.
30.03.2020 Publication accepted
"High tumor necrosis factor-α production of stimulated blood cells predicts response to Infliximab in inflammatory bowel disease"
Clinical Gastroenterology and Hepatology
21.02.2020 Publication accepted
"Use of microbiological and patient data for choice of empirical antibiotic therapy in acute cholangitis"
22.01.2020 Publication accepted
(Cooperation with AG Machelska, Experimental Anesthesiology, Charite)
"Interleukin-4 induces M2 macrophages to produce sustained analgesia via opioids"
01.01.2020 Website reboot