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News der AG Siegmund "Chronische Darmentzündung"

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13.10.2022 Publication accepted
(Cooperation with AG Zundler from the Uniklinikum Erlangen)
"Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease"
Translational Research

04.10.2022  We welcome a new member of our team
Anna-Maria Eleftheriadou joins the lab as clinician scientist.

08.08.2022 We welcome a new member of our team
Toka Omar joins the lab as research scientist / PhD student.

05.07.2022 Publication accepted
"Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease."
EMBO Mol Med.

13.06.2022 Publication accepted
(Cooperation with Ahmed Hegazy and Thomas Schneider from our Department)
"Anti-SARS-CoV2 antibody-mediated cytokine release syndrome in a patient with acute promyelocytic leukemia"
BMC Infectious Diseases

27.05.2022 Collaborative Research Center/ Transregio (TRR) 241
„Immun-Epithelial Communication in Inflammatory Bowel Disease“ extended.
- Project: "Mesenteric Fat - an immunological barrier in Crohn's Disease?"

12.04.2022 Editorial accepted
"Epithelial RAC1 niches in IBD: from barrier integrity to cytoskeletal plasticity."
Gut

04.04.2022  We welcome a new member of our team
Catharina Kramer joins the lab as clinician scientist.

04.04.2022 Editorial accepted
"Targeting SOCE in intestinal epithelial cells as a new treatment concept for IBD?"
CMGH

01.04.2022 Marina Kolesnichenko leaves the group
Marina joins the colleagues from the Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie at the Campus Virchow Klinikum.

08.03.2022 Publication accepted
(Cooperation with AG Keller, Department of Hematology, Oncology and Cancer Immunology, Charité)
"Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer"
Journal of Clinical Investigation

28.02.2022 Cansu Yerinde and Lorenz Gerbeth leave the group
After about five years in our labs, Cansu Yerinde and Lorenz Gerbeth leave the group. Cansu is joining the lab of Debattama Sen at the Massachusetts General Hospital Center for Cancer Research in Boston. Lorenz will move to the R&D Department at Bayer AG in Wuppertal. We wish them all the best.

07.02.2022 Publication accepted
(Cooperation with AG von Schwarzenberg, Department of Endocrinology & Metabolism, Charité)
"Effects of caloric restriction on the gut microbiome are linked with immune senescence"
Microbiome

21.01.2022 Short Talk Award acquired
Marilena Letizia was awarded the Short Talk Award of the "5th German Mass Cytometry User Forum"

19.01.22 Publication accepted
(Cooperation with AG Scheffold, Institute of Immunology, Christian-Albrechts-University of Kiel)
"A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4 + T cells and is defective in Crohn´s disease patients "
Mucosal Immunology

11.01.2022 Publication accepted
"Early onset of TNFα-driven arthritis, auto-inflammation and progressive loss of vision in a patient with ALPK1 mutation"
Journal of Clinical Immunology

05.01.2022 A Review has been published
"Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion"
Cancers
https://doi.org/10.3390/cancers14010250

09.12.2021 Publication accepted
(Cooperation with AG Rauch, Medizinische Klinik für Kardiologie, Charité)
"Pleiotropic effects of the protease-activated receptor 1 (PAR1)
inhibitor, vorapaxar, on atherosclerosis and vascular inflammation"
Cells

19.10.2021 Cansu Yerinde successfully defended her PhD thesis.
We congratulate Dr. rer. nat. Yerinde on her graduation.

03.08.2021 Publication accepted
"Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells"
Mucosal Immunology

12.07.2021 ECRT seed grant acquired
Our team, consisting of Max Brunkhorst, Lorenz Gerbeth, Marcus Lindner (from the AG Weinhart, FU Berlin) and Jörn Ziegler (alphabetical order), acquired the "Einstein Kickbox - Young Scientist grant within the Einstein Center for Regenerative Therapies (ECRT)"

23.06.2021 Publication accepted
(Cooperation with AG Qin, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China)
"Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes"
iScience

19.06.2021 Research award acquired
Carl Weidinger was awarded the DACED Zukunftspreis 2021

15.06.2021 "BIH Translation Hub Organoids and Cell Engineering" Grant accepted
"To investigate the influence of Store-Operated Calcium Entry on the homeostasis of intestinal epithelial cells"

15.06.2021 We welcome a new member of our team
Marina Kolesnichenko joins the lab as a new PI.

11.06.2021 Poster prize acquired
Marliena Letizia won the poster prize of the "Vision 2030: Changing Paradigms in IBD" conference.

03.05.2021 We welcome a new member of our team
Nadra Alzain joins the lab as research scientist / PhD student.

11.04.2021 Publication accepted
(Cooperation with AG Mechsner, Endometriosis Research Center, Charité)
"Functional changes of immune cells: signal of immune tolerance of the ectopic lesions in endometriosis?"
Reproductive BioMedicine Online

26.03.2021 A Review has been published
"Histone Deacetylases in the Inflamed Intestinal Epithelium-Promises of New Therapeutic Strategies"
Frontiers in Medicine
https://doi.org/10.3389/fmed.2021.655956

20.03.2021 A book chapter has been published
"Fatty Acid–Driven Polarization of Suppressive Bone Marrow–Derived Macrophages Including Metabolic and Functional Analysis"
Metastasis: Methods in Molecular Biology
https://doi.org/10.1007/978-1-0716-1350-4_14

12.03.2021 A Review has been published
"Location is important: differentiation between ileal and colonic Crohn’s disease"
Nature Reviews Gastroenterology & Hepatology
https://doi.org/10.1038/s41575-021-00424-6

09.03.2021 Yasmina Rodriguez Sillke successfully defended her PhD thesis.
We congratulate Dr. rer. nat. Rodriguez Sillke on her graduation.

25.02.2021 A Review has been published
"Recognition of food antigens by the mucosal and systemic immune system: Consequences for intestinal development and homeostasis"
International Journal of Medical Microbiology
https://doi.org/10.1016/j.ijmm.2021.151493

19.02.2021 A Review has been published
"COVID-19—from mucosal immunology to IBD patients"
Mucosal Immunology
https://doi.org/10.1038/s41385-021-00384-9

01.01.2021 DKTK Research Grant starting
Lea-Maxie Haag acquired the "Initial Funding within the Young Investigator Grant of the German Cancer Consortium (DKTK)"

26.11.2020 Collaborative Research Center (SFB) 1449 "Dynamic Hydrogels at Biointerfaces" accepted
- Projekt "Hydrogel properties on intestinal surfaces in health and disease" in collaboration with AG Weinhart (FU Berlin)
- Core unit: "In vitro and in vivo hydrogel model systems core unit" in collaboration with AG Weinhart and AG Mall (BIH)

15.11.2020 We welcome a new member of our team
Adrian Huck joins the lab as research scientist / PhD student.

01.10.2020  We welcome a new member of our team
Max Brunkhorst joins the lab as clinician scientist.

28.08.2020 Scholarships acquired
Cansu Yerinde and Lorenz Gerbeth both acquired the competitive "Promotionsabschlussstipendium I" (graduation scholarship) of the Charité Nachwuchskommission, which covers one year of funding.

03.08.2020 Yasmina Rodriguez Sillke leaves the group
After almost four years in our labs and after finishing the experimental part of her thesis, Yasmina joins the Charité/BIH - Cytometry Core. We wish her all the best.

05.06.2020 Poster prize acquired
Marilena Letizia was awarded the poster prize of the TRR241 iRTG for "The pharmacologic inhibition of Store-operated Calcium Entry pathwy in inflammatory bowel disease"

18.05.2020 DFG Research Grant accepted
"Der Fettsäuremetabolismus immunsuppressiver myeloider Zellen in der Tumormikroumgebung als neues therapeutisches Ziel."

11.05.2020 Publication accepted
(Cooperation with the Stein Lab "Translational Oncology of Solid Tumors", MDC)
"Pro-inflammatory TNF-a and IFN-g Promote Tumor Growth and Metastasis via Induction of MACC1"
Frontiers in Immunology

01.04.2020 We welcome a new member of our team 
Julia Hecker joins the lab as research scientist / PhD student.

30.03.2020 Publication accepted
"High tumor necrosis factor-α production of stimulated blood cells predicts response to Infliximab in inflammatory bowel disease"
Clinical Gastroenterology and Hepatology

21.02.2020 Publication accepted
"Use of microbiological and patient data for choice of empirical antibiotic therapy in acute cholangitis"
BMC Gastroenterology

22.01.2020 Publication accepted
(Cooperation with AG Machelska, Experimental Anesthesiology, Charite)
"Interleukin-4 induces M2 macrophages to produce sustained analgesia via opioids"
JCI Insight

01.01.2020 Website reboot